Pantoprazole 20mg suppresses the symptoms of acid reflux for up to 24 hours. Available to buy online from Dr Fox.

Pantoprazole rated 5/5 in 7 reviews

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Buy pantoprazole online in UK

How to order pantoprazole 20mg from our online pharmacy for UK delivery:

  1. Read medical information about acid reflux treatment
  2. Answer medical questions to check for eligibility
  3. Order reviewed by doctors - medication posted from UK pharmacy (Royal Mail Tracked 24)


Medication Quantity Cost
Pantoprazole 20mg 28 tablets £7.90
Pantoprazole 20mg 56 tablets £13.00

Price match guarantee
Prescription issued online - small prescription fee per order.

Prescription fees

Dr Fox supplies medicine on prescription and charges a small prescription fee based on the order value of each prescription.

Prescriptions are issued by our doctors online and sent electronically to our pharmacy.

Order value Prescription fee
up to £10 £1.00
up to £20 £2.00
up to £40 £3.00
over £40 £4.00

If you have your own private paper prescription please post to our pharmacy (details).

Dr Fox prices are 25%–50% lower than other UK online clinics.

Delivery charges

UK delivery only: £2.90 per consultation via Royal Mail Tracked 24 Signed For (1-2 working days with tracking).

Parcel forwarding services are not permitted. Use only UK home or work delivery address.

Returns and refunds - unwanted items can be returned within 14 working days for a full refund.

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About pantoprazole

  • Pantoprazole tablets 20mg tablets are prescription-only medicine used to treat acid reflux.
  • Take one pantoprazole 20mg tablet once a day at the same time each day.
  • Read the patient leaflet for a full list of side effects, cautions, and interactions with other drugs.

Pantoprazole tablets belong to the class of medicines called proton pump inhibitors (PPI). PPIs were discovered in 1979 and pantoprazole has been used for over 30 years. PPIs are safe and effective treatments for acid reflux/heartburn, Gastro-oesophageal reflux disease (GORD) and dyspepsia/indigestion, and can also help a range of other gastric and duodenal conditions.

Further information: NHS - Pantoprazole.

How does pantoprazole relieve acid reflux/heartburn?

The 'proton pump' is the process which produces digestive acid in the stomach in response to eating a meal. Pantoprazole and other PPIs block the proton pump and so reduce the acidity in the stomach. As there is less acid the symptoms of acid reflux and heartburn are reduced.

How to take pantoprazole 20mg tablets

  • Take one pantoprazole 20mg tablet once a day, one hour before a meal, at the same time each day.
  • Swallow your tablets whole with a drink of water.
  • Do not chew or crush the tablets.
  • Use daily for up to 4 weeks. If symptoms do not settle after 2 weeks, consult a GP to discuss further investigation.
  • If symptoms come back, take one pantoprazole 20mg tablet once a day, as needed.
  • If needing to continue use more than 4 times a week for over a month, consult a GP.

How soon is pantoprazole effective?

There should be some improvement from taking pantoprazole within a few days. For best results follow the instructions carefully on how to take it - see above and read the patient leaflet supplied in packs.

Consult a GP if symptoms have not significantly settled after 2 weeks.

Who might be suitable for pantoprazole 20mg tablets?

Dr Fox supplies pantoprazole 20mg tablets to treat dyspepsia and Gastro-oesophageal reflux disease (GORD), with symptoms of acid reflux, acid indigestion, and heartburn in adults over 18.

Pantoprazole can also be used:

  • To prevent relapse in healed oesophagitis.
  • To prevent gastroduodenal ulcers due to taking continuous NSAID (non steroidal anti-inflammatory) treatment.
  • For other conditions linked to overproduction of stomach acid.

Helicobacter pylori (H. pylori)

H. pylori is a bacterium found in some people's stomachs. It is known to be linked with gastritis, gastric and duodenal ulcers, and gastric cancer. All PPIs, including pantoprazole, can be used in combination with certain antibiotics, to clear H. pylori from the stomach. A GP will often test for H. pylori if symptoms of acid reflux, indigestion, and heartburn do not settle quickly with a PPI. The test is usually either a simple stool (poo) test or a breath test. For the test to be reliable, you must not have taken a PPI in the past 2 weeks, or antibiotics in the past 4 weeks.

Is there anyone who cannot take pantoprazole?

There are checks in the online consultation to confirm if pantoprazole is suitable or may affect other medications taken.

If taking phenytoin (for fits) or warfarin type anticoagulants (blood thinners requiring regular blood tests) speak to the GP about extra monitoring before taking pantoprazole.

If taking medication to treat HIV/AIDS or cancer chemotherapy, including methotrexate, do not take pantoprazole without discussing with your specialist as pantoprazole may interfere with your treatment.

Pantoprazole may not be suitable for people with severe liver or kidney problems - consult a GP.

During treatment with pantoprazole, if new symptoms develop such as unintended weight loss, vomiting, swallowing difficulties, blood in vomit, or dark and tarry stools, or new stomach pains you must seek urgent medical attention.

Inform the doctor or nurse if undergoing investigations or blood tests, that you are taking pantoprazole.

Are there any drugs which might interact with pantoprazole?

There are a few medicines which interact with pantoprazole, making one or other less or more effective. Checks for these are carried out in the online consultation.

Do not take pantoprazole if taking:

  • Nelfinavir, rilpivirine, atazanavir, saquinavir and ritonavir, tipranivir, or similar - for HIV

Discuss with your GP/specialist before taking pantoprazole if taking:

  • Dasatinib, gefitinib, neratinib, erlotinib - cancer chemotherapy.
  • Fluvoxamine for depression.
  • Ketoconazole, posaconazole, voriconazole, and itraconazole - antifungals.
  • Methotrexate - cancer chemotherapy, rheumatoid arthritis, and psoriasis.
  • Phenytoin - fits.
  • Rifampicin - tuberculosis.
  • St John's Wort - herbal remedy for low mood.
  • Warfarin - blood thinning.

Pregnancy and/or breastfeeding

There is no information about the safety of pantoprazole in pregnancy or breastfeeding so pantoprazole should not be used, without first discussing with a GP or specialist. Pantoprazole is found in breast milk.

Potential side effects of pantoprazole

All medications can cause side effects but not everyone gets them.

Side effects are less commonly reported with pantoprazole than other PPIs, but can include:

  • Headache.
  • Constipation or diarrhoea.
  • Flatulence (wind).
  • Nausea/vomiting.
  • Stomach pains.
  • Small harmless stomach polyps (only seen on endoscopy and settle on stopping the medication).

Further information is in the manufacturer's patient leaflet.

Special warnings/precautions for use

If you are due to have a gastroscopy/endoscopy you will probably be asked to stop taking pantoprazole a few weeks before the procedure - check with your GP.

The following have been reported with long-term (over a year) regular use of PPIs including pantoprazole:

  • Slight increase in the risk of fractures at the hip, wrist, and spine, hence patients are recommended to follow national guidelines for prevention and treatment of osteoporosis, and to have an adequate intake of calcium and vitamin D. Risk is increased if also taking regular steroid medication.
  • Low levels of vitamin B12. If you already have low vitamin B12 levels, discuss with a GP before taking pantoprazole tablets.
  • Low magnesium levels. Symptoms include fatigue, dizziness, confusion, fits, and irregular heart rhythms. More likely if taken with other drugs (e.g. digoxin) which can also lower magnesium levels. Periodic checks of blood magnesium levels may be recommended if taking for longer than 3 months continuously.
  • A rare condition 'subacute cutaneous lupus erythematosus' (SCLE). Consult your GP promptly if you develop a skin rash on sunlight exposed areas.
  • A slightly higher risk of gastroenteritis such as Campylobacter and Salmonella.

Very rare effects:

  • Dizziness, visual disturbances, and muscular weakness - if affected do not drive or operate heavy machinery.
  • In some uncommon cases pantoprazole can lead to blood changes, so if having any blood test, always let your GP or nurse know that you are taking it.

Allergy to pantoprazole and other PPIs

Do not take pantoprazole if you are known to be allergic to other PPIs.

If you have any symptoms or signs suggestive of an acute allergic reaction (anaphylaxis), you must get medical help immediately (telephone 999 if in the UK).

Symptoms/signs of an acute allergic reaction include:

  • Difficulty breathing, tight chest, wheezing.
  • Swelling of the face, lips, or tongue.
  • Skin rash – urticaria/hives.
  • Confusion/collapse/unconsciousness.

For more information see NHS - Anaphylaxis.

Patient Information Leaflet

Illustration of patient leaflet from medicine packet

The Patient Information Leaflet (PIL) is the leaflet included in the pack with a medicine and must be read before taking the medicine. It is written for patients and gives information about taking or using a medicine.

Pantoprazole Patient Leaflet

Pantoprazole FAQs

Does pantoprazole contain lactose?

No. Pantoprazole tablets are lactose free.

Can I take pantoprazole together with another PPI for a better result?

No. You should not take more than one PPI at the same time. If your symptoms are not controlled with a standard dose of one PPI then consult your GP as you may need further tests.

See also acid reflux FAQs page.

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Dr Amanda Wood

Authored 11 March 2021 by Dr A. Wood
MB ChB Manchester University 1984. NHS GP in Bristol. GMC no. 2855422

Reviewed by Dr C. Pugh, Dr B. Babor
Last reviewed 05 December 2023
Last updated 19 January 2024
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Recent Pantoprazole reviews

Pantoprazole rated 5/5 in 7 product reviews

See over 40,000 service reviews of Dr Fox


Prompt delivery highly recommended

Tue/12/2023 23:52
Anonymous Verified


Useful meds for my GERD! However, very much helped by taking a probiotic in the morning.

Thu/11/2023 09:38
Anonymous Verified


Great product and great value

Wed/03/2023 21:56
Anonymous Verified


Good product

Tue/01/2023 22:09
Anonymous Verified


Has cleared up my heart burn after a couple of weeks of taking - would heartily recommend

Wed/06/2022 13:14
P. Dredge Verified

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