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How does Colofac work?

Colofac contains the active ingredient mebeverine, an anticholinergic medicine, that directly relaxes bowel spasm, whilst allowing the bowel to continue to work effectively. Mebeverine is effective at treating colicky abdominal pain and cramps, excessive wind (flatulence), and can help with loose stools/diarrhoea.

Mebeverine is also available as a drink combination with ispaghula husk (Fybogel).

Can anyone take Colofac?

Most people with IBS are able to take Colofac.

It is important to be sure that your symptoms are caused by IBS and not something more serious.

If any of the following apply, check with your GP before using Colofac:

• Changed or new symptoms especially in women.
• Over 40 years old with first symptoms.
• New symptoms of blood in your stool or motions.
• Feeling nauseous or loss of appetite.
• Losing weight without dieting.
• Pale and tired.
• Severely constipated.
• Running a high temperature (fever).
• Travelled abroad recently.
• Are or may be pregnant.
• Urinary symptoms as well.

Colofac is licensed for use in adults only and is not recommended for use in children.

Taking Colofac with other medicines

Colofac is suitable to take with most other medications, but do not take at the same time as other antispasmodics, e.g. Spasmonal (alverine) or Buscopan (hyoscine).

Can Colofac be used in pregnancy and whilst breastfeeding?

In general, all medication should be avoided whilst trying for pregnancy, and when pregnant or breastfeeding.

There are no studies about the safety of Colofac during pregnancy or whilst breastfeeding so it should not be used.

Side effects of Colofac

Most people experience no side effects at all from Colofac.

However as with any medication there is a risk of allergy ranging from mild skin reactions to the more severe anaphylaxis. Severe allergic reactions to Colofac are extremely rare. If you have reacted to an antispasmodic medication in the past, do not try a different antispasmodic as the reaction is likely to be the same.

Further information on side effects can be found in the manufacturer's patient information leaflets.

How to take Colofac

Colofac 135mg tablets

Take one Colofac 135mg sugar-coated tablet 3 times a day about 20 minutes before meals as gut spasms are usually strongest after eating. Symptoms should improve within 2 hours.

Colofac MR 200mg capsules

Colofac MR 200mg are slow release capsules which are taken twice daily in the morning and evening, providing a more constant treatment. Swallow one capsule whole with a glass of water. Do not chew as this destroys the slow release mechanism.

Other measures to help symptoms of IBS

Diarrhoea and bloating - reduce insoluble fibre like bran, wholegrain bread, and brown rice. Reduce caffeine, alcohol, fizzy drinks, and gas-producing foods like beans and cabbage.

Constipation - try adding more soluble fibre like oats and linseed, or soluble fibre supplements like Fybogel (ispaghula). Increase the soluble fibre gradually or bloating and wind may get worse. It may take several weeks for optimal benefits.

Regular physical activity is also helpful for the bowels. Aim for 30 minutes of moderate activity at least 5 days per week.

It is also important to drink plenty of fluids (at least 8 cups per day) when constipated, especially if taking Fybogel.

Further information

• NHS - IBS - Diet, lifestyle and medicines
• NHS - Mebeverine